Do I need to know how a synchrotron works?
There's no need for you to fully understand how a synchrotron works, or even the finer details of the technique, we'll take care of that. If you would like to come to Diamond and see the experiment take place, you would be very welcome. If you'd prefer to wait for the report, that's great too.
What is the Wellcome Trust synchrotron science facility?
Funded in 2002 by the UK Government, through the Science and Technology Facility Council and the Wellcome Trust, it is the UK’s national synchrotron science facility. The synchrotron is free at the point of access through a competitive application process, provided that the results are in the public domain.
How does Diamond work with its industrial partners?
Some of our industrial partners collaborate directly with Diamond and Diamond staff through studentships, post-doctoral research associates and longer term projects and grants.
How far in advance should you register for a remote access visit?
Registration for a full remote access visit must be completed in the user administration system as soon as possinble, ideally 5 working days in advance. Provide contact details for all users which will be using the beamline for the whole duration of the experiment, when registering in UAS.
Who is responsible for loading and unloading all the pucks for a mixed access visit?
The local users are responsible for loading/unloading all the pucks for a mixed access visit.
Can you run experiments remotely?
Running experiments completely remotely is increasingly popular , removing the need to travel to Diamond, increasing user participation per session and for some shift modes it is compulsory. To help Diamond maintain a high level of service to support this and to avoid disappointment at peak periods the following applies to Full Remote Access sessions:
Where is Diamond Light Source?
Diamond Light Source is a 3 GeV synchrotron on the Harwell Science and Innovation Campus in South Oxfordshire, United Kingdom. Funded in 2002 by the UK Government, through the Science and Technology Facility Council and the Wellcome Trust, it is the UK’s national synchrotron science facility.
Is a synchrotron free?
The synchrotron is free at the point of access through a competitive application process, provided that the results are in the public domain. Over 7000 researchers from both academia and industry use Diamond to conduct experiments, assisted by approximately 650 staff.
What is the function of Foxp2?
Because FOXP2 is a transcription factor, it is located in the nucleus of cells and its role is to bind to the promotor region of certain genes and facilitate/regulate their transcription to mRNA which ultimately results in the translation and thus expression of that particular protein. Therefore, the regulation of transcription (and hence translation) of any protein will have a direct effect on the functioning of that protein. Our focus is thus on transcriptional regulation because it is the process that initiates downstream effects and predicts which genes will be turned on or off and hence, crudely put, controls the way we function.
Can crystals be sent to Diamond?
The opportunities to send crystals to Diamond with the assistance of the GCRF START grant have been revolutionary in enabling us to have fast and remote access to diffraction and data collection that would otherwise have been logistically far more difficult to achieve, and therefore far more sparsely accomplished. Unfortunately, up to now, crystallisation in this project has been a challenge and so far, we are yet to achieve the crystals we require. The fact that the proteins we are attempting to crystallise have not yet had their structures solved and published in the Global Protein Data Bank (PDB) attests to the challenge we knew we would face in obtaining good diffraction data. And while we have obtained some crystals successfully, none of the data we have obtained has been worthy of solving the structure. Nevertheless, the fact that we can obtain crystals is promising and I am determined to persevere with this work until we are successful.
Is ASD genetically determined?
The number with ASD has increased over the years reflecting both an increase in awareness as well as a potential increase in environmental triggers although the disorder is currently believed to be predominantly genetically determined.
